The syndrome of resistance to thyroid stimulating hormone.

Abstract excerpt

Resistance to thyroid stimulating hormone (TSH) is a syndrome of reduced sensitivity to a biologically active TSH molecule. Subjects have elevated TSH levels but no goiter. However, thyroid hormone concentration may vary from normal to very high, depending on the severity of the resistance. Individuals with very high TSH, low thyroxine (T4) and hypoplastic thyroid glands can be mistakenly diagnosed as having...

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