Article
Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist.
Virology - 20 Jun 2011
Killip M J, Young D F, Ross C S, Chen S, Goodbourn S, Randall R E
Abstract excerpt
It is generally thought that pathogen-associated molecular patterns (PAMPs) responsible for triggering interferon (IFN) induction are produced during virus replication and, to limit the activation of the IFN response by these PAMPs, viruses encode antagonists of IFN induction. Here we have studied the induction of IFN by parainfluenza virus type 5 (PIV5) at the single-cell level, using a cell line expressing GFP...
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