[Blood coagulation parameters in children with acute promyelocytic leukemia, their changes during all-trans retinoic acid treatment, and causes of hemorrhagic and thrombotic events].

Abstract excerpt

The specific feature of acute promyelocytic leukemia (APL) is blood coagulation impairments that appear as thrombohemorrhagic disorders with a possible fatal outcome. The pathogenesis of bleeding in APL is due to the properties of leukemic promyelocytes; however, little is known about the causes of venous thrombosis in APL. This circumstance determined the objective of the investigation, which was to study the...

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