Article
Gonadal pathology and tumor risk in relation to clinical characteristics in patients with 45,X/46,XY mosaicism.
The Journal of clinical endocrinology and metabolism - 1 Jul 2011
Cools M, Pleskacova J, Stoop H, Hoebeke P, Van Laecke E, Drop S L S, Lebl J, Oosterhuis J W, Looijenga L H J, Wolffenbuttel K P
Abstract excerpt
CONTEXT: Gonadectomy is avoided whenever possible in boys with 45,X/46,XY. However, no clinical markers are currently available to guide clinicians in predicting gonadal tumor risk or hormone production. OBJECTIVE: The objective of the study was to test the hypothesis that gonadal histology and risk for development of a malignant germ cell tumor are reflected by the clinical presentation of a 45,X/46,XY...
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