Article
Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage.
The Journal of pathology - 1 Jun 2011
de Andrea Carlos E, Prins Frans A, Wiweger Malgorzata I, Hogendoorn Pancras C W
Abstract excerpt
Proteoglycans are secreted into the extracellular matrix of virtually all cell types and function in several cellular processes. They consist of a core protein onto which glycosaminoglycans (e.g., heparan or chondroitin sulphates), are attached. Proteoglycans are important modulators of gradient formation and signal transduction. Impaired biosynthesis of heparan sulphate glycosaminoglycans causes osteochondroma,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.