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Article

Voltage-dependent gating underlies loss of ENaC function in Pseudohypoaldosteronism type 1.

Biophysical journal - 20 Apr 2011

Kucher Volodymyr, Boiko Nina, Pochynyuk Oleh, Stockand James D

Abstract excerpt

Here we explore the mechanism and associated structure-function implications of loss of function for epithelial Na(+) channel (ENaC) containing a pseudohypoaldosteronism type 1 (PHA-1)-causing missense point mutation. As expected, human ENaC that contained subunits harboring PHA-1-causing substitutions within an absolutely conserved, cytosolic Gly residue (e.g., βG37S) had significantly less activity....

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Identifiers

PMID: 21504729
DOI: 10.1016/j.bpj.2011.02.046
PMCID: PMC3077708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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