Article
Sialidase and sialoglycoproteases can modulate virulence in Porphyromonas gingivalis.
Infection and immunity - 1 Jul 2011
Aruni Wilson, Vanterpool Elaine, Osbourne Devon, Roy Francis, Muthiah Arun, Dou Yuetan, Fletcher Hansel M
Abstract excerpt
The Porphyromonas gingivalis recombinant VimA can interact with the gingipains and several other proteins, including a sialidase. Sialylation can be involved in protein maturation; however, its role in virulence regulation in P. gingivalis is unknown. The three sialidase-related proteins in P. gingivalis showed the characteristic sialidase Asp signature motif (SXDXGXTW) and other unique domains. To evaluate the...
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