Article
dN/dS-based methods detect positive selection linked to trade-offs between different fitness traits in the coat protein of potato virus Y.
Molecular biology and evolution - 1 Sept 2011
Moury Benoît, Simon Vincent
Abstract excerpt
The dN/dS ratio between nonsynonymous and synonymous substitution rates has been used extensively to identify codon positions involved in adaptive processes. However, the accuracy of this approach has been questioned, and very few studies have attempted to validate experimentally its predictions. Using the coat protein (CP) of Potato virus Y (PVY; genus Potyvirus, family Potyviridae) as a case study, we...
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