Article
The role of single nucleotide polymorphisms of the ERCC1 and MMS19 genes in predicting platinum-sensitivity, progression-free and overall survival in advanced epithelial ovarian cancer.
Gynecologic oncology - 1 Aug 2013
Moxley K M, Benbrook D M, Queimado L, Zuna R E, Thompson D, McCumber M, Premkumar P, Thavathiru E, Hines L, Moore K N
Abstract excerpt
OBJECTIVE: This study aims to assess the role of polymorphisms in DNA repair genes, excision repair cross-complementation group 1 (ERCC1) and methyl-methanesulfonate sensitivity 19 (MMS19), in tumor response to platinum-based chemotherapy and survival in advanced epithelial ovarian cancer (EOC). METHODS: Single nucleotide polymorphism (SNP) analysis was performed on the paraffin-embedded tumor tissue of women...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.