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Mammalian Sperm Acrosome Reaction: Where Does It Begin Before Fertilization?

13 Apr 2011

Abstract excerpt

Spermatozoa of many animal species, including humans, must undergo a Ca þ -dependent exocytotic process known as the acrosome reaction (AR) before fertilizing oocytes. The AR, first described in the sea urchin and starfish by Dan [1, 2], involves multiple fusions of the outer acrosomal membrane with the overlying sperm plasma membrane. This allows release of the contents of the acrosome to the outside of the...

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PMID: 21490244
DOI: 10.1095/biolreprod.111.092601

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