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Article

Gamete activation: basic knowledge and clinical applications

1 Jun 2016

Abstract excerpt

BACKGROUND: The first clues to the process of gamete activation date back to nearly 60 years ago. The mutual activation of gametes is a crucial event during fertilization. In the testis and ovaries, spermatozoa and oocytes are in a state of meiotic and metabolic quiescence and require reciprocal signals in order to undergo functional changes that lead to competence for fertilization. First, the oocyte activates...

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PMID: 27278231
DOI: 10.1093/humupd/dmw014

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