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Yeast Two Hybrid Analyses Reveal Novel Binary Interactions between Human Cytomegalovirus-Encoded Virion Proteins

1 Apr 2011

Abstract excerpt

Human cytomegalovirus (HCMV) is the largest human herpesvirus and its virion contains many viral encoded proteins found in the capsid, tegument, and envelope. In this study, we carried out a yeast two-hybrid (YTH) analysis to study potential binary interactions among 56 HCMV-encoded virion proteins. We have tested more than 3,500 pairwise combinations for binary interactions in the YTH analysis, and identified 79...

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PMID: 21483780
DOI: 10.1371/journal.pone.0017796

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