Article
Sex ratio of the mutation frequencies in haemophilia A: estimation and meta-analysis.
Human genetics - 1 Dec 1990
Rosendaal F R, Bröcker-Vriends A H, van Houwelingen J C, Smit C, Varekamp I, van Dijck H, Suurmeijer T P, Vandenbroucke J P, Briët E
Abstract excerpt
A hereditary disease with excess mortality such as haemophilia is maintained in the population by the occurrence of new cases, i.e. mutations. In haemophilia, mutations may arise in female or male ancestors of a 'new' patient. The ratio of the mutation frequencies in males over females determines...
Topics
- Female
- Gene Frequency
- Hemophilia A
- Humans
- Male
- Meta-Analysis as Topic
- Models, Genetic
- Mutation
- Sex Ratio