Germ-line origins of mutation in families with hemophilia B: the sex ratio varies with the type of mutation.

Article

Germ-line origins of mutation in families with hemophilia B: the sex ratio varies with the type of mutation.

American journal of human genetics - 1 Jan 1993

Ketterling R P, Vielhaber E, Bottema C D, Schaid D J, Cohen M P, Sexauer C L, Sommer S S

Abstract excerpt

Previous epidemiological and biochemical studies have generated conflicting estimates of the sex ratio of mutation. Direct genomic sequencing in combination with haplotype analysis extends previous analyses by allowing the precise mutation to be determined in a given family. From analysis of the...

Topics

Adolescent
Adult
Age Factors
Factor IX
Female
Germ Cells
Hemophilia B
Humans
Male
Mutation
Pedigree
Sex Factors
Statistics as Topic

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