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Synthesis and biological evaluation of bilobol and adipostatin A

1 Apr 2011

Abstract excerpt

Concise total synthesis of bilobol 5-pentadecenylresorcinol (1), isolated from Gingko biloba fruits, has been achieved in 10 steps with 51% overall yield from 3,5-dihydroxybenzoic acid (3). Adipostatin A (2), isolated from the fruits as well as from Streptomyces cyaneus 2299-SV1, has also been synthesized in two steps from methylated bilobol (10). The structure-activity relationship study of synthetic products...

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PMID: 21462031
DOI: 10.1080/10286020.2011.554828

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