Article
Understanding the physical basis of the salt dependence of the electrostatic binding free energy of mutated charged ligand-nucleic acid complexes.
Biophysical chemistry - 1 Jun 2011
Harris Robert C, Bredenberg Johan H, Silalahi Alexander R J, Boschitsch Alexander H, Fenley Marcia O
Abstract excerpt
The predictions of the derivative of the electrostatic binding free energy of a biomolecular complex, ΔG(el), with respect to the logarithm of the 1:1 salt concentration, d(ΔG(el))/d(ln[NaCl]), SK, by the Poisson-Boltzmann equation, PBE, are very similar to those of the simpler Debye-Hückel equation, DHE, because the terms in the PBE's predictions of SK that depend on the details of the dielectric interface are...
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