Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IVSII-666 of human beta-globin gene: a polymorphic marker linked to codon 8(-AA) mutation.

Genetic testing and molecular biomarkers - 1 Jan 2000

Akhavan-Niaki Haleh, Seresti Siamak Shafiezadeh, Asghari Beheshteh, Banihashemi Ali

Abstract excerpt

AIMS: IVSII-666 (C-T) is one of the polymorphic sites located in the second intron of the β-globin gene. Its polymorphism rate and relationship to a specific mutation are studied for the first time on 211 DNA samples of thalassemia trait patients living in Mazandaran province in North Iran using Ssp1 restriction enzyme. β-Globin haplotype determination at XmnI/(G)γ, HincII/3'Ψβ, HinfI/5'β, RsaI/5'β, and SspI/β...

Topics

Codon
Deoxyribonucleases, Type II Site-Specific
Haplotypes
Heterozygote
Homozygote
Humans
Iran
Mutation
Polymorphism, Genetic
Prenatal Diagnosis
Thalassemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

beta-Globins

Source

Identifiers

PMID: 21453056
DOI: 10.1089/gtmb.2010.0242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21453056-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IVSII-666 of human beta-globin gene: a polymorphic marker linked to codon 8(-AA) mutation.PMID 21453056Read ↗

A Rare Heterozygote with a Novel IVS-Ⅱ-786 (T>A) Mutation on β-Globin Gene in a Patient with Thalassemia.Semantic proximity Read ↗

Beta-thalassemia intermedia from southern Iran: IVS-II-1 (G-->A) is the prevalent thalassemia intermedia allele.Semantic proximity Read ↗

Molecular analysis of Iranian families with sickle cell disease.Semantic proximity Read ↗

A novel polymorphism causes a different restriction pattern by RsaI in the beta-globin gene cluster: application in prenatal diagnosis.Semantic proximity Read ↗

Prenatal diagnosis of beta-thalassemia in the West Bank and Gaza.Semantic proximity Read ↗

Association between Different Polymorphic Markers and β-Thalassemia Intermedia in Central Iran.Semantic proximity Read ↗

Molecular detection of Spanish deltabeta-thalassemia associated with beta-thalassemia identified during prenatal diagnosis.Semantic proximity Read ↗

Prenatal Molecular Diagnosis of β-Thalassemia and Sickle Cell Anemia in the Syrian PopulationSemantic proximity Read ↗

Postnatal and non-invasive prenatal detection of β-thalassemia mutations based on Taqman genotyping assays.Semantic proximity Read ↗

Description of a Rare β-Globin Gene Mutation: -86 (C>G) (HBB: c.-136C>G) Observed in a Syrian Family.Semantic proximity Read ↗

A rare mutation [IVS-I-130 (G-A)] in a Turkish beta-thalassemia major patient.Semantic proximity Read ↗

Identification of Mutations Causing Aberrant Termination and Deficient Splice Donor Site on the HBA1 Gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.