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Article

Long-term follow-up of childhood-onset hypopituitarism in patients with the PROP-1 gene mutation.

Hormone research - 1 Jan 2003

Pavel Marianne E, Hensen Johannes, Pfäffle Roland, Hahn Eckhart G, Dörr Helmuth G

Abstract excerpt

OBJECTIVE: The PROP-1 gene mutation is a rare disorder leading to combined pituitary hormone deficiencies over time. The aim was to analyze the clinical picture of 40 years of an almost untreated PROP-1 gene mutation. METHODS: We describe the clinical and hormonal data of 2 brothers from childhood to adulthood as well as imaging procedures (MRI of the pituitary gland, bone mineral density by QCT and DPX). The...

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Identifiers

PMID: 14530604
DOI: 10.1159/000073228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Long-term follow-up of childhood-onset hypopituitarism in patients with the PROP-1 gene mutation.PMID 14530604Read ↗

Hypopituitarism in five PROP1 mutation siblings: long-lasting natural course and the effects of growth hormone replacement introduction in middle adulthood.Semantic proximity Read ↗

Familial combined pituitary hormone deficiency caused by PROP-1 gene mutation. Growth patterns and MRI studies in untreated subjects.Semantic proximity Read ↗

Long-term follow-up of combined pituitary hormone deficiency in two siblings with a Prophet of Pit-1 gene mutation.Semantic proximity Read ↗

PROP-1 gene mutations in a 63-year-old woman presenting with osteoporosis and hyperlipidaemia.Semantic proximity Read ↗

The natural history of the R120C PROP1 mutation reveals a wide phenotypic variability in two untreated adult brothers with combined pituitary hormone deficiency.Semantic proximity Read ↗

PROP-1 gene mutation (R120C) causing combined pituitary hormone deficiencies with variable clinical course in eight siblings of one Jewish Moroccan family.Semantic proximity Read ↗

Comparison of clinical characteristics of a pediatric cohort with combined pituitary hormone deficiency caused by mutation of the PROP1 gene or of other origins.Semantic proximity Read ↗

PROP1 gene analysis in Portuguese patients with combined pituitary hormone deficiency.Semantic proximity Read ↗

The spectrum of hypopituitarism caused by PROP1 mutations.Semantic proximity Read ↗

A familial form of congenital hypopituitarism due to a PROP1 mutation in a large kindred: phenotypic and in vitro functional studies.Semantic proximity Read ↗

Clinical characteristics of a pediatric cohort of patients with combined pituitary insufficiency caused by mutations of the PROP1 geneSemantic proximity Read ↗

Clinical and Biochemical Phenotype of Familial Anterior Hypopituitarism from Mutation of the PROP1 GeneSemantic proximity Read ↗

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