Article
Risk Stratification of Type 2 Long-QT Syndrome Mutation Carriers With Normal QTc Interval: The Value of Sex, T-Wave Morphology, and Mutation Type.
Circulation. Arrhythmia and electrophysiology - 1 Jul 2018
Platonov Pyotr G, McNitt Scott, Polonsky Bronislava, Rosero Spencer Z, Kutyifa Valentina, Huang Allison, Moss Arthur J, Zareba Wojciech
Abstract excerpt
BACKGROUND: Long-QT (LQT) syndrome mutation carriers have higher risk of cardiac events than unaffected family members even in the absence of QTc prolongation. Changes in T-wave morphology may reflect penetrance of LQT syndrome mutations. We aimed to assess whether T-wave morphology may improve risk stratification of LQT2 mutation carriers with normal QTc interval. METHODS: LQT2 mutation carriers with QTc <460 ms...
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