Article
Genome-wide expression profiling of urinary bladder implicates desmosomal and cytoskeletal dysregulation in the bladder exstrophy-epispadias complex.
International journal of molecular medicine - 1 Jun 2011
Qi Lihong, Chen Kun, Hur David J, Yagnik Garima, Lakshmanan Yegappan, Kotch Lori E, Ashrafi Gerald H, Martinez-Murillo Francisco, Kowalski Jeanne, Naydenov Cyrill, Wittler Lars, Gearhart John P, Draaken Markus, Reutter Heiko, Ludwig Michael, Boyadjiev Simeon A
Abstract excerpt
The bladder exstrophy-epispadias complex (BEEC) represents a spectrum of urological abnormalities where part, or all, of the distal urinary tract fails to close during development, becoming exposed on the outer abdominal wall. While the etiology of BEEC remains unknown, strong evidence exists that genetic factors are implicated. To understand the pathways regulating embryonic bladder development and to identify...
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