Article
A potential role for targeted therapy in a subset of metastasizing adnexal carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2011
Dias-Santagata Dora, Lam Quynh, Bergethon Kristin, Baker Gabrielle M, Iafrate A John, Rakheja Dinesh, Hoang Mai P
Abstract excerpt
Metastasizing adnexal carcinomas are rare; thus, currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target cancer-promoting pathways may complement conventional therapeutic approaches. We performed immunohistochemistry (epidermal growth factor receptor (EGFR), HER2, and CD117), EGFR and ERBB2 fluorescence in situ hybridization (FISH), and multiplexed SNaPshot® genotyping...
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