Article

Novel organoid-based exploration reveals the role of LMTK3/FADS2 signaling in metastatic breast cancer progression in felines and humans

2025-09-09

Abstract excerpt

<title>Abstract</title> <p> Cancer research in veterinary medicine is still under development compared to human medicine. Feline breast cancer (FBC) is highly malignant, intractable, and has the potential to become a valuable model for human metastatic BC (HBC). We developed primary FBC organoids and analyzed their morphology, gene expression patterns, and response to anti-cancer drugs. FBC organoids recapitulat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30135fe1-5f69-5b85-b11e-394d3e57e059
DOI: 10.21203/rs.3.rs-7396289/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel organoid-based exploration reveals the role of LMTK3/FADS2 signaling in metastatic breast cancer progression in felines and humansDOI 10.21203/rs.3.rs-7396289/v1Read

Molecular Mechanisms of Feline CancersSemantic proximity Read

A living biobank of canine mammary tumor organoids as a comparative model for human breast cancerSemantic proximity Read

Patient-derived organoid models of malignant phyllodes tumours for drug sensitivity testing and identification of targeted therapeutic strategies.Semantic proximity Read

Comparative proteomic analysis in human and canine breast cancer cell line: identification of proteins linked to lipid dynamics and functionsSemantic proximity Read

Establishment of a direct 2.5D organoid culture model using companion animal cancer tissuesSemantic proximity Read

Exploring the Therapeutic Potential of BRCA1 and BRCA2 as Targets in Canine Oncology: A Comprehensive Review of Their Role in Cancer Development and TreatmentSemantic proximity Read

Tumor microenvironment of human breast cancer, and feline mammary carcinoma as a potential study model.Semantic proximity Read

A living biobank of canine mammary tumor organoids as a comparative model for human breast cancerSemantic proximity Read

Establishment and characterization of a tumoroid biobank derived from dog patients’ mammary tumors for translational researchSemantic proximity Read

Transcriptome Signatures of Canine Mammary Gland Tumors and Its Comparison to Human Breast CancersSemantic proximity Read

The Flint Animal Cancer Center (<scp>FACC</scp>) Canine Tumour Cell Line Panel: a resource for veterinary drug discovery, comparative oncology and translational medicineSemantic proximity Read

Spontaneous Feline Mammary Carcinoma Is a Model of HER2 Overexpressing Poor Prognosis Human Breast CancerSemantic proximity Read