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Article

The essential carboxyl group in subunit c of the F1F0 ATP synthase can be moved and H(+)-translocating function retained.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990

Miller M J, Oldenburg M, Fillingame R H

Abstract excerpt

The proteolipid subunit c of F1F0-type H(+)-transporting ATP synthases [ATP phosphohydrolase (H(+)-transporting), EC 3.6.1.34] contains a conserved Asp/Glu residue that is thought to function in H+ translocation. To test the importance of the position of this residue in the Escherichia coli enzyme, we used oligonucleotide-directed mutagenesis to move the carboxyl side chain from position 61 to position 58, 60, or...

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Identifiers

PMID: 2142302
DOI: 10.1073/pnas.87.13.4900
PMCID: PMC54228

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