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Article

Caffeine synergizes with another coffee component to increase plasma GCSF: linkage to cognitive benefits in Alzheimer's mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Cao Chuanhai, Wang Li, Lin Xiaoyang, Mamcarz Malgorzata, Zhang Chi, Bai Ge, Nong Jasson, Sussman Sam, Arendash Gary

Abstract excerpt

Retrospective and prospective epidemiologic studies suggest that enhanced coffee/caffeine intake during aging reduces risk of Alzheimer's disease (AD). Underscoring this premise, our studies in AD transgenic mice show that long-term caffeine administration protects against cognitive impairment and reduces brain amyloid-β levels/deposition through suppression of both β- and γ-secretase. Because coffee contains...

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Identifiers

PMID: 21422521
DOI: 10.3233/JAD-2011-110110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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