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Article

In vitro recovery of ATP-sensitive potassium channels in β-cells from patients with congenital hyperinsulinism of infancy.

Diabetes - 1 Apr 2011

Powell Philippa D, Bellanné-Chantelot Christine, Flanagan Sarah E, Ellard Sian, Rooman Raoul, Hussain Khalid, Skae Mars, Clayton Peter, de Lonlay Pascale, Dunne Mark J, Cosgrove Karen E

Abstract excerpt

OBJECTIVE: Congenital hyperinsulinism in infancy (CHI) is characterized by unregulated insulin secretion from pancreatic β-cells; severe forms are associated with defects in ABCC8 and KCNJ11 genes encoding sulfonylurea receptor 1 (SUR1) and Kir6.2 subunits, which form ATP-sensitive K(+) (K(ATP)) channels in β-cells. Diazoxide therapy often fails in the treatment of CHI and may be a result of reduced cell surface...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21411514
DOI: 10.2337/db10-1443
PMCID: PMC3064095

Genes

ABCC8
KCNJ11
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vitro recovery of ATP-sensitive potassium channels in β-cells from patients with congenital hyperinsulinism of infancy.PMID 21411514Read ↗

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