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Article

Severity ranking of non-deletional alpha thalassemic alleles: insights from an Omani family study.

European journal of haematology - 1 Jun 2011

Wali Yasser, Zadjali Shoaib Al, Elshinawy Mohamed, Beshlawi Ismail, Fawaz Naglaa, Alkindi Salam, Rawas Abdulhakim, Alsinani Siham, Daar Shahina, Krishnamoorthy Rajagopal

Abstract excerpt

In an Omani family, four different alpha thalassemic alleles, one single-gene deletional (-α(3.7) ) and three non-deletional forms (α(TSaudi) , α(Δ5nt) , and α(ΔG) ), interact in various combinations and result in two distinct hematological phenotypes, with and without HbH inclusions. After excluding the presence of potential genetic modifiers, viz associated β-thalassemic alleles or functional alpha hemoglobin...

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PMID: 21410534
DOI: 10.1111/j.1600-0609.2011.01606.x

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AHSP

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