Article
A gene's ability to buffer variation is predicted by its fitness contribution and genetic interactions.
PloS one - 2 Mar 2011
Wang Guang-Zhong, Liu Jian, Wang Wei, Zhang Hong-Yu, Lercher Martin J
Abstract excerpt
BACKGROUND: Many single-gene knockouts result in increased phenotypic (e.g., morphological) variability among the mutant's offspring. This has been interpreted as an intrinsic ability of genes to buffer genetic and environmental variation. A phenotypic capacitor is a gene that appears to mask phenotypic variation: when knocked out, the offspring shows more variability than the wild type. Theory predicts that this...
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