Article
Exome resequencing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in Japanese.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2011
Yamaguchi Tetsutaro, Hosomichi Kazuyoshi, Narita Akira, Shirota Tatsuo, Tomoyasu Yoko, Maki Koutaro, Inoue Ituro
Abstract excerpt
Massively parallel sequencing of target regions, exomes, and complete genomes has begun to increase the opportunities for identifying genetic variants underlying rare and common diseases dramatically. Here we applied exome resequencing to primary failure of tooth eruption (PFE) to identify the genetic causality of the disease. Two Japanese families having PFE were recruited and examined by genome-wide linkage...
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