Article
Effect of UDP-glucuronosyltransferase 2B15 polymorphism on bisphenol A glucuronidation.
Archives of toxicology - 1 Nov 2011
Hanioka Nobumitsu, Oka Hiroyuki, Nagaoka Kenjiro, Ikushiro Shinichi, Narimatsu Shizuo
Abstract excerpt
Bisphenol A (BPA) is one of a number of potential endocrine-disrupting chemicals, which are metabolized mainly by UDP-glucuronosyltransferase 2B15 (UGT2B15) in humans. Six UGT2B15 allelic variants (UGT2B15*2, UGT2B15*3, UGT2B15*4, UGT2B15*5, UGT2B15*6, and UGT2B15*7; wild-type, UGT2B15*1) with amino acid substitutions have been found in Caucasian, African-American, Hispanic, and Oriental populations to date. In...
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