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Article

First report of multiple CEBPA mutations contributing to donor origin of leukemia relapse after allogeneic hematopoietic stem cell transplantation.

Blood - 12 May 2011

Xiao Haowen, Shi Jimin, Luo Yi, Tan Yamin, He Jingsong, Xie Wanzhuo, Zhang Lifei, Wang Yingjia, Liu Lizhen, Wu Kangni, Yu Xiaohong, Cai Zhen, Lin Maofang, Ye Xiujin, Huang He

Abstract excerpt

Donor cell leukemia after allogeneic hematopoietic stem cell transplantation might provide a unique human model for our understanding of leukemogenesis in vivo. We hypothesized that the "2-genetic-hits model" may contribute to the "leukemization" of donor cells and first evaluated these genetic mutations that are implicated in the development of acute myeloid leukemia in a donor cell leukemia patient and donor....

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Share to CCAAT-Enhancer-Binding Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Hematopoietic Stem Cell Transplantation

Share to Leukemia, Myeloid, Acute

Share to Neoplasm Recurrence, Local

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Source

Identifiers

PMID: 21403128
DOI: 10.1182/blood-2010-12-326322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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