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Article

5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder.

Psychiatric genetics - 1 Oct 2011

Douglas Kara, Chan Grace, Gelernter Joel, Arias Albert J, Anton Raymond F, Poling James, Farrer Lindsay, Kranzler Henry R

Abstract excerpt

INTRODUCTION: Antisocial personality disorder (ASPD) frequently co-occurs with substance dependence (SD). A functional polymorphism (5-HTTLPR) in the serotonin transporter gene has been widely studied as a risk factor for a variety of psychopathologic conditions including aggressive/violent behavior. Childhood abuse is an important predictor of ASPD. We examined 5-HTTLPR genotype and adverse childhood events...

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Identifiers

PMID: 21399568
DOI: 10.1097/YPG.0b013e3283457c15
PMCID: PMC3119731

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Source receipt: pubmed, retrieved 7 Sept 2026.

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