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Can clinical and molecular epidemiologic parameters guide empiric treatment with vancomycin for methicillin-resistant Staphylococcus aureus infections?

Diagnostic microbiology and infectious disease - 1 May 2011

Yamaki Jason, Lee Michelle, Shriner Kimberly A, Wong-Beringer Annie

Abstract excerpt

Reports of vancomycin treatment failure for infections caused by susceptible methicillin-resistant Staphylococcus aureus (MRSA) strains with elevated minimum inhibitory concentration (MIC) has prompted use of high-dose therapy, but nephrotoxicity is a concern. We determined whether clinical and molecular epidemiologic parameters can be used to guide empiric vancomycin therapy and strain susceptibility to...

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PMID: 21392923
DOI: 10.1016/j.diagmicrobio.2010.12.003

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