Temozolomide Treatment for Aggressive Pituitary Tumors: Correlation of Clinical Outcome with O⁶-Methylguanine Methyltransferase (MGMT) Promoter Methylation and Expression

Abstract excerpt

CONTEXT: The typically indolent behavior of pituitary tumors is juxtaposed with high rates of tumor cell invasion into adjacent dural structures, and occasional aggressive behavior. Although clinically significant invasion and malignant transformation remain uncommon, there are limited treatment options available for the management of these aggressive tumors. Recently, case reports have described efficacy of...

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