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Identification of a Soluble Form of B7-H1 That Retains Immunosuppressive Activity and Is Associated with Aggressive Renal Cell Carcinoma

25 Feb 2011

Abstract excerpt

PURPOSE: Release of inhibitory coregulatory proteins into the circulation may represent one mechanism by which tumors thwart immune responses. Our objective was to determine whether soluble B7-H1 (sB7-H1) levels in patients with clear cell renal cell carcinoma (ccRCC) are associated with pathologic features and patient outcome. EXPERIMENTAL DESIGN: We developed an ELISA for quantification of sB7-H1 in biological...

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PMID: 21355078
DOI: 10.1158/1078-0432.ccr-10-0250

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