Article
Promise and pitfalls of the Immunochip.
Arthritis research & therapy - 1 Feb 2011
Cortes Adrian, Brown Matthew A
Abstract excerpt
Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of common and rare variants to map the remaining heritability and to fine-map established loci, the...
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