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Article

Fertilization in C. elegans requires an intact C-terminal RING finger in sperm protein SPE-42.

BMC developmental biology - 23 Feb 2011

Wilson Luke D, Sackett Jacqueline M, Mieczkowski Bryce D, Richie Abigail L, Thoemke Kara, Rumbley Jon N, Kroft Tim L

Abstract excerpt

BACKGROUND: The C. elegans sperm protein SPE-42, a membrane protein of unknown structure and molecular function, is required for fertilization. Sperm from worms with spe-42 mutations appear normal but are unable to fertilize eggs. Sequence analysis revealed the presence of 8 conserved cysteine residues in the C-terminal cytoplasmic domain of this protein suggesting these residues form a zinc-coordinating RING...

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Identifiers

PMID: 21345212
DOI: 10.1186/1471-213X-11-10
PMCID: PMC3053230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fertilization in C. elegans requires an intact C-terminal RING finger in sperm protein SPE-42.PMID 21345212Read ↗

The spe-42 gene is required for sperm-egg interactions during C. elegans fertilization and encodes a sperm-specific transmembrane protein.Semantic proximity Read ↗

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SPE-51, a sperm-secreted protein with an immunoglobulin-like domain, is required for fertilization in C. elegansSemantic proximity Read ↗

Characterization of <i>spe-40/Fam187</i> identifies a deeply conserved sperm protein at the <i>C. elegans</i> fertilization synapseSemantic proximity Read ↗

The Caenorhabditis elegans spe-38 gene encodes a novel four-pass integral membrane protein required for sperm function at fertilization.Semantic proximity Read ↗

spe-29 encodes a small predicted membrane protein required for the initiation of sperm activation in Caenorhabditis elegans.Semantic proximity Read ↗

SPE-44 Implements Sperm Cell FateSemantic proximity Read ↗

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spe-12 encodes a sperm cell surface protein that promotes spermiogenesis in Caenorhabditis elegans.Semantic proximity Read ↗

SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans.Semantic proximity Read ↗

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