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Article

A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.

Microbial biotechnology - 1 Mar 2011

Nárdiz Nuria, Santamarta Irene, Lorenzana Luis M, Martín Juan F, Liras Paloma

Abstract excerpt

A protein highly overrepresented in the proteome of Streptomyces clavuligerus oppA2::aph was characterized by MS/MS as a rhodanese-like enzyme. The rhlA gene, encoding this protein, was deleted from strains S. clavuligerus ATCC 27064 and S. clavuligerus oppA2::aph to characterized the RhlA enzyme activity, growth on different sulfur sources and antibiotic production by the mutants. Whereas total thiosulfate...

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Identifiers

PMID: 21342467
DOI: 10.1111/j.1751-7915.2010.00222.x
PMCID: PMC3818862

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