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Article

Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth.

Nature cell biology - 1 Mar 2011

Kume Kazunori, Koyano Takayuki, Kanai Muneyoshi, Toda Takashi, Hirata Dai

Abstract excerpt

Microtubules are central to eukaryotic cell morphogenesis. Microtubule plus-end tracking proteins (+TIPs) transport polarity factors to the cell cortex, thereby playing a key role in both microtubule dynamics and cell polarity. However, the signalling pathway linking +TIPs to cell polarity control remains elusive. Here we show that the fission yeast checkpoint kinase Cds1 (Chk2 homologue) delays the transition of...

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PMID: 21336311
DOI: 10.1038/ncb2166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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