Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors.

Cellular oncology (Dordrecht, Netherlands) - 1 Feb 2011

Jotzu Constantin, Alt Eckhard, Welte Gabriel, Li Jie, Hennessy Bryan T, Devarajan Eswaran, Krishnappa Srinivasalu, Pinilla Severin, Droll Lilly, Song Yao-Hua

Abstract excerpt

BACKGROUND: Carcinoma-associated fibroblasts (CAF) are considered to contribute to tumor growth, invasion and metastasis. However, the cell type of origin remains unknown. Since human adipose tissue derived stem cells (hASCs) are locally adjacent to breast cancer cells and might directly interact with tumor cells, we investigated whether CAFs may originate from hASCs. METHODS: hASCs cultured under different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Chemokine CCL5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CXCL12

Share to Culture Media, Conditioned

Share to Myofibroblasts

Share to Tenascin

Share to Transforming Growth Factor beta1

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 21327615
DOI: 10.1007/s13402-011-0012-1
PMCID: PMC13014585

Genes

CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors.PMID 21327615Read ↗

Breast fibroblasts in both cancer and normal tissues induce phenotypic transformation of breast cancer stem cells: a preliminary studySemantic proximity Read ↗

Altered features and increased chemosensitivity of human breast cancer cells mediated by adipose tissue-derived mesenchymal stromal cells.Semantic proximity Read ↗

Recent discoveries concerning the tumor - mesenchymal stem cell interactionsSemantic proximity Read ↗

Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic StrategiesSemantic proximity Read ↗

Adipose Stem Cells and Cancer: Concise ReviewSemantic proximity Read ↗

The role of multipotent cancer associated fibroblasts in hepatocarcinogenesis.Semantic proximity Read ↗

Hepatocellular carcinoma cell line-microenvironment induced cancer-associated phenotype, genotype and functionality in mesenchymal stem cells.Semantic proximity Read ↗

Impact of Human Adipose Tissue-Derived Stem Cells on Malignant Melanoma Cells in An In Vitro Co-culture ModelSemantic proximity Read ↗

Fibroblast-dependent regulation of the stem cell properties of cancer cells.Semantic proximity Read ↗

Interaction Between Breast Cancer Cells and Adipose Tissue Cells Derived from Fat Grafting.Semantic proximity Read ↗

Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblastsSemantic proximity Read ↗

Comparative analysis of adipose-derived mesenchymal stem cells isolated from abdominal and breast tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.