Article
Novel alleles of HLA-DQ and -DR loci show association with recurrent miscarriages among South Indian women.
Human reproduction (Oxford, England) - 1 Apr 2011
Aruna Meka, Nagaraja Theeya, Andal Bhaskar Sadaranga, Tarakeswari Surapaneni, Reddy Alla Govardhan, Thangaraj Kumarasamy, Singh Lalji, Reddy B Mohan
Abstract excerpt
BACKGROUND In this study, recurrent miscarriages (RMs) are defined as loss of two or more clinically detectable pregnancies before 20 weeks of gestation. HLA has been thought to play a role in RM. However, the results of earlier studies on the role of different human leucocyte antigen (HLA) genes were conflicting and inconclusive. In the present study, we investigate HLA genes (HLA-DRA, HLA-DRB1, HLA-DQA1 and...
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