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NSR-seq transcriptional profiling enables identification of a gene signature of Plasmodium falciparum parasites infecting children

16 Feb 2011

Abstract excerpt

Malaria caused by Plasmodium falciparum results in approximately 1 million annual deaths worldwide, with young children and pregnant mothers at highest risk. Disease severity might be related to parasite virulence factors, but expression profiling studies of parasites to test this hypothesis have been hindered by extensive sequence variation in putative virulence genes and a preponderance of host RNA in clinical...

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PMID: 21317536
DOI: 10.1172/jci43457

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