Article
Visualization of intracellular trafficking of Math1 protein in different cell types with a newly-constructed nonviral gene delivery plasmid.
The journal of gene medicine - 1 Feb 2011
Zhang Weikai, Zhang Ya, Sood Rohit, Ranjan Sanjeev, Surovtseva Elena, Ahmad Aqeel, Kinnunen Paavo K J, Pyykkö Ilmari, Zou Jing
Abstract excerpt
BACKGROUND: In recent years, Math1 gene therapy was indicated to be the future therapy for deafness in combination with other growth factors. However, Math1 delivery using adenovirus-mediated gene delivery or electroporation was impractical. The contribution of Math1 in the combined procedure was not clearly elucidated using the existing plasmids. Nonviral gene delivery vectors are expected to be extremely safe...
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