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Article

Importance of serine727 phosphorylated STAT1 in IFNγ-induced signaling and apoptosis of human salivary gland cells.

International journal of rheumatic diseases - 1 Feb 2011

Tsuboi Hiroto, Wakamatsu Ei, Iizuka Mana, Nakamura Yumi, Sugihara Makoto, Suzuki Takeshi, Ogishima Hiroshi, Hayashi Taichi, Goto Daisuke, Ito Satoshi, Matsumoto Isao, Sumida Takayuki

Abstract excerpt

AIM: It is reported that in salivary glands of Sjögren's syndrome (SS), interferon gamma (IFNγ) and IFNγ-inducible genes containing signal transducers and activators of transcription 1 (STAT1) are upregulated and play a crucial role in the pathogenesis of SS. The aim of this study is to clarify which phosphorylation of STAT1, serine727 (Ser(727)) or tyrosine701 (Tyr(701)) of STAT1, is important for IFNγ signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21303487
DOI: 10.1111/j.1756-185X.2010.01575.x

Genes

STAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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