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Article

Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth

7 Feb 2011

Abstract excerpt

The mammalian fetus represents a semiallograft within the maternal uterus yet is not rejected. This situation is particularly pronounced in species with a hemochorial type of placentation, such as humans and rodents, where maternal tissues and blood are in direct contact with fetal trophoblast and thus potentially with paternal antigens. The main polymorphic antigens responsible for graft rejection are MHC...

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PMID: 21300875
DOI: 10.1073/pnas.1005342108

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