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Article

Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome.

Fertility and sterility - 1 Apr 2011

Xu Ning, Kim Hyung-Goo, Bhagavath Balasubramanian, Cho Sung-Gyu, Lee Jae Ho, Ha Kyungsoo, Meliciani Irene, Wenzel Wolfgang, Podolsky Robert H, Chorich Lynn P, Stackhouse Kathryn A, Grove Anna M H, Odom Lawrence N, Ozata Metin, Bick David P, Sherins Richard J, Kim Soo-Hyun, Cameron Richard S, Layman Lawrence C

Abstract excerpt

OBJECTIVE: To determine if mutations in NELF, a gene isolated from migratory GnRH neurons, cause normosmic idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome (KS). DESIGN: Molecular analysis correlated with phenotype. SETTING: Academic medical center. PATIENT(S): A total of 168 IHH/KS patients as well as unrelated control subjects were studied for NELF mutations. INTERVENTION(S): NELF coding...

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Identifiers

PMID: 21300340
DOI: 10.1016/j.fertnstert.2011.01.010
PMCID: PMC3888818

Genes

IHH
TACR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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