Article
Severe combined immunodeficiency in Frisian Water Dogs caused by a RAG1 mutation.
Genes and immunity - 1 Jun 2011
Verfuurden B, Wempe F, Reinink P, van Kooten P J S, Martens E, Gerritsen R, Vos J H, Rutten V P M G, Leegwater P A
Abstract excerpt
Mortality of pups at 8-12 weeks of age was frequently observed in Frisian Water Dogs. Blood parameters and clinical signs of newborns from three litters were monitored. Three pups from two litters showed strongly reduced levels of immunoglobulins and lymphocytes. These dogs were euthanized after first display of disease. Concurrent clinical and pathological features were consistent with a diagnosis of severe...
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