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Article

Association of genetic polymorphisms of CXCL12/SDF1 gene and its receptor, CXCR4, to the susceptibility and prognosis of non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2011

Lee Yao-Ling, Kuo Wu-Hsien, Lin Chiao-Wen, Chen Wei, Cheng Wei-Erh, Chen Shuo-Chueh, Shih Chuen-Ming

Abstract excerpt

BACKGROUND: The aim of this study was to evaluate the relations of chemokine CXCL12, previously known as stromal cell-derived factor-1 (SDF1), and its receptor, CXCR4, gene variants on non-small cell lung cancer (NSCLC) risk and disease severity. METHODS: Through a case-control study design, genomic DNA samples of 247 NSCLC patients and 328 age and sex-matched controls were subjected to polymerase chain...

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Source

Identifiers

PMID: 21292343
DOI: 10.1016/j.lungcan.2010.12.011

Genes

CXCL12
CXCR4

Provenance

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