Accuracy and computational efficiency of a graphical modeling approach to linkage disequilibrium estimation.

Abstract excerpt

We develop recent work on using graphical models for linkage disequilibrium to provide efficient programs for model fitting, phasing, and imputation of missing data in large data sets. Two important features contribute to the computational efficiency: the separation of the model fitting and phasing-imputation processes into different programs, and holding in memory only the data within a moving window of loci...

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