Article
Association of common variants in ERBB4 with congenital left ventricular outflow tract obstruction defects.
Birth defects research. Part A, Clinical and molecular teratology - 1 Mar 2011
McBride Kim L, Zender Gloria A, Fitzgerald-Butt Sara M, Seagraves Nikki J, Fernbach Susan D, Zapata Gladys, Lewin Mark, Towbin Jeffrey A, Belmont John W
Abstract excerpt
BACKGROUND: The left ventricular outflow tract (LVOT) defects aortic valve stenosis (AVS), coarctation of the aorta (COA), and hypoplastic left heart syndrome (HLHS) represent an embryologically related group of congenital cardiovascular malformations. They are common and cause substantial morbidity and mortality. Prior evidence suggests a strong genetic component in their causation. METHODS: We selected NRG1,...
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