Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 Lesions in Leukemic Transformation

2 Feb 2011

Abstract excerpt

To the Editor: Myeloproliferative neoplasms have an inherent tendency toward leukemic transformation. The genetic mechanisms of transformation remain largely unknown. We analyzed biopsy specimens of myeloproliferative neoplastic tissue from 330 patients for chromosomal aberrations associated with leukemic transformation (the analysis was performed with the use of Genome-Wide Human SNP [single-nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Chronic Myeloid Leukemia Treatments
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21288114
DOI: 10.1056/nejmc1012718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

p53 Lesions in Leukemic TransformationPMID 21288114Read ↗

Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome–negative myeloproliferative neoplasmsSemantic proximity Read ↗

Genomic aberrations of myeloproliferative and myelodysplastic/myeloproliferative neoplasms in chronic phase and during disease progression.Semantic proximity Read ↗

Identification of genomic aberrations associated with disease transformation by means of high-resolution SNP array analysis in patients with myeloproliferative neoplasm.Semantic proximity Read ↗

Leukemic transformation in myeloproliferative neoplasms: therapy-related or unrelated?Semantic proximity Read ↗

Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation.Semantic proximity Read ↗

Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias.Semantic proximity Read ↗

AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasmsSemantic proximity Read ↗

SNP array karyotyping allows for the detection of uniparental disomy and cryptic chromosomal abnormalities in MDS/MPD-U and MPD.Semantic proximity Read ↗

Genetic lesions associated with blastic transformation of polycythemia vera and essential thrombocythemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.